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Under the influence of ferrous ions or lipoxygenases, the overexpressed unsaturated fatty acids on the cell membrane undergo lipid peroxidation, thereby inducing cell death

Abbreviations CDKs: Cyclin-dependent kinases CDK5: Cyclin-dependent kinase-5 GSTP1: Glutathione S-transferase P1 EMT: Epithelial Mesenchymal Transition MTC: Medullary thyroid carcinoma ADD1: Adducin1 PPAR: Peroxisome proliferator-activated receptor PCa: Prostate cancer PDX: Patient-derived xenograft PDAC: Pancreatic ductal adenocarcinoma Ral GEFs: Ral guanine nucleotide-exchange factors EZH2: Enhancer of zeste homolog GBM: Glioblastoma PIKE: A-Phosphatidylinositol 3 kinase enhancer-A CRMP2: Collapsin response mediator protein 2 ACSS2: Acetyl-CoA synthetase 2 OGT: O-GlcNAc transferase DYRK1A: Dual-specificity tyrosine phosphorylation-regulated kinase 1 A HCC: Hepatocellular carcinoma PRMT1: Protein arginine methyltransferase 1 SCLCs: Small cell lung cancer NSCLCs: Non-small cell lung cancer LUAD: Lung adenocarcinoma hASH1: Achaete-scute homolog-1 CAP1: Adenylate cyclase associated protein 1 PD: L1-Programmed cell death ligand 1 IFN: Interferon HNSCC: Head and neck squamous cell carcinoma MM: Multiple myeloma EphA4: Eph receptor A4 ATM: Ataxia Telangiectasia Mutated DLC: 1-Deleted in Liver Cancer 1 FAK: Focal adhesion kinase PIPKI90: Phosphatidylinositol 4-phosphate 5-kinase type I 90 ERK: Extracellular signal-regulated kinase TRIM59: Tripartite motif-containing 59 RPA32: Replication protein A ESRP1: Epithelial Splicing Regulatory Protein 1 DRP1: Dynamin-related protein 1 TIGAR: TP53 induced-glycolysis regulatory phosphatase CK2: Casein kinase 2 mPTP: Mitochondrial permeability transition pore AR: Androgen receptor TNBC: Triple-negative breast cancer STAT: Signal transducer and activator of transcription References Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, et al

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