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doi: 10.1016/j.biopha.2017.08.132 45 WuGYangQYuYLinSFengYLvQet al

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In the crystal structure of the hetero-complex parts of this region were not visible in the electron density and are not connected to the core structure of the 6-cysteine domain (PDB 7S7Q) ( Figure 4 To date only single and tandem 6-cysteine domains have been structurally characterized by NMR and X-ray crystallography

For platinum-resistant patients: when azacitidine was combined with valproic acid and carboplatin, 18.8% of patients achieved stable disease or minor response, but the study was terminated early due to a high rate of grade 3 or higher adverse events [170]