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A 2012 Cochrane Review of pooled data from three trials examining tracheostomy-free survival in 974 patients treated with riluzole and 503 placebo-treated patients demonstrated a statistically significant increase in survival from 11.8 months to 14.8 months, but without any benefit on measures of muscle strength

There is overwhelming evidence that demonstrates that elevated calcium concentration, inflammation, increased oxidative stress, as well as a reduction in blood flow, are some of the pathophysiological mechanisms underlying NIHL (Figure 1

All participants were asked to abstain from taking any nutritional supplements including: vitamins, minerals, and any over the counter products

Putra et al., 2016