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Illustratively, BPC 157 (as an original anti-ulcer peptide, stable in human gastric juice more than 24 h unlike standard growth factors rapidly destroyed, and thereby easy applicable, lethal dose (LD1) not achieved, used to be in ulcerative colitis trials and now multiple sclerosis [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17]), within wound/healing gastrointestinal ulcer relations and angiogenesis is advantageous over standard growth angiogenic factors [7]

Non-approved peptides showed promising preclinical and limited clinical evidence but lack long-term safety data and systematic validation