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They also illustrate an important distinction: increasing a laboratory measure of glutathione is not automatically proof that supplementation prevents disease, improves longevity or produces a noticeable clinical benefit

No B12 deficient patient wants to have more injections than they need, they simply want a frequency that keeps them well and completely able to function

Using rectal administration to achieve systemic activity is preferred when the drug is destroyed in the GI tract, if oral administration is not possible because of vomiting, or the patient is unconscious or incapable of swallowing oral formulations