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Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility

While local GABA concentrations are generally negatively related to stimulus-induced cortical activity, positive correlation between glutamate concentrations and inter-regional activity relationships has been reported (Duncan et al., 2014)

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1 McGinley graduated from Bryant High School in 1941, and he joined the Army Air Corps a week later hoping to become an airplane mechanic, but he became a tail gunner instead