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It accelerates degradation

This results in joint pain, deformity, and disability (Yoo et al., 2009)

The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I

Since tumor cells with certain oncogenic mutations are very sensitive to ferroptosis, triggering ferroptosis may also have significant therapeutic potential for ferroptosis-sensitive tumor cells ( c /GSH/GPX4 axis have been shown to be fatal in host cells