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Experimental animals All animal experimental protocols were in accordance with the ethical guidelines for Animal Experimentation of the National Research Council of Thailand and were approved by the Animal Ethics Committee of Khon Kaen University (IACUC-KKU-65/65 and IACUC-KKU-52/61)

Second, given the complexity of PD pathogenesis, developing multi-target synergistic therapies capable of simultaneously intervening in multiple critical pathways is particularly crucial

The input ERA5 low-resolution data are both the target variables and the additional fields used as dynamical predictors to improve models' performance