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The researchers monitored miRNA expression over 6, 12, and 24 months while patients followed a weight-loss diet

309 When IgE binds to FcRI to trigger immunity, FcRI aggregation induces a variety of signaling pathways to regulate the secretion of allergy-associated mediators, including histamines and leukotrienes, and induces the transcription of Th2 cytokines and tumor necrosis factor (TNF) genes, 310 which leads to potentially life-threatening allergic diseases

McKenzie SJ, Baker MS, Buffinton GD, and Doe WF (1996)

The Efficacy and Mechanism of Removal of Organic Substances from Water by Ozone and Activated Carbon