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In RA pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit proliferative features similar to tumor cells and subsequently cause cartilage erosion, which will eventually lead to joint destruction (1, 2)

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10.1016/j.jep.2023.116289 180 WuY.LiuL.ZhaoY.LiX.HuJ.LiH.et al (2024b)

The effect of maternal embryonic leucine zipper kinase pharmacological inhibitors, which suppress ferroptosis in intestinal tissue and alleviate intestinal inflammation in mice with colitis, is closely related to the regulation of the gut microbiota [90]