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The principle lipase implicated in TBI is cytoplasmic phospholipase A2 (cPLA2), which is upregulated after in vivo and in vitro experimental TBI and preferentially cleaves arachidonic acid as an essential part of enzymatic lipid peroxidation and inflammatory signal transduction [82]

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The three libraries were generated using error-prone PCR as described above, using the following conditions to produce varying levels of mutagenesis: Library 1: 30 M 8-oxo-dGTP, 1 M dPTP, 20 PCR cycles Library 2: 20 M 8-oxo-dGTP, 2 M dPTP, 20 PCR cycles Library 3: 10 M 8-oxo-dGTP, 3 M dPTP, 20 PCR cycles The library sizes (approximated by number of transformants as described above) were 6 10 7 for each library

Product Highlights: Offers broad spectrum support across multiple regenerative cellular programs Aids DNA repair and helps reset epigenetic programming Supports stem cell renewal processes Aids a healthy inflammatory response and immune function Helps collagen, elastin, and glycosaminoglycan synthesis and aids tissue health Supports neurological and cardiovascular health and function These statements have not been evaluated by the Food and Drug Administration