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showed that in cultured rat ventricular myocytes, trimetazidines beneficial effects were only observed when cells were undergoing hypoxia and not during normoxia, highlighting trimetazidine as a metabolic regulator that would not increase mitochondrial function in healthy states [123]

These mechanisms, although they play different roles in different situations, are essential for maintaining metabolic homeostasis and neuroprotection in the body

Diabetes 63 (10), 31993209

76 In agreement with this hypothesis, downregulating PTEN expression reportedly inhibits extra-synaptic NMDAR currents and protects neurons from experimental ischemic injury