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In this coordinated system, GSH provides rapid copper sequestration and distribution capacity, whereas certain MTs serve as high-affinity copper reservoirs that limit metal toxicity

Although it is currently not clear if tamoxifen is effective in targeting other types of drug resistant cells that over-express P-gp, based on our current understanding of the mechanism of collateral sensitivity of P-gp-overexpressing cells, we speculate that tamoxifen alone or in combination with rotenone could reduce the rise of drug resistant tumor cells

The use of nanocarriers to deliver drugs, proteins, and nucleic acids has been widely exploited in the medical sciences (Zhang et al., 2022a)

Equal amounts of protein from cell lysates were separated by 420% SDSPAGE