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In summary, PDK2 contributes to cisplatin resistance by sustaining glycolytic metabolism, altering the mitochondrial membrane potential, regulating ion homeostasis, enhancing stemness, and modulating ROS signaling

The majority of the complex projects below, into the matrix (the bottom of the picture, in this orientation) although a significant amount also protrudes into the intermembrane space

doi: 10.1093/jn/132.5.1012 114 HoseinifarS

Furthermore, an open-label, phase I/IIa study investigated the combination of hydrogen water and photobiomodulation (PBM) therapy, demonstrating a significant reduction in Unified PD Rating Scale (UPDRS) scores after 1e week of treatment