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It works by reducing the absorption of sodium from the small intestine and colon, resulting in an increase in water secretion into the intestinal lumen, resulting in an increase in bowel movements and a decrease in abdominal pain in patients with IBS-C

(PubMed) Schwab U, Torronen A, Toppinen L, et al

In addition, the implementation of PHD significantly improved several cardiovascular metabolic indices, including a reduction in systolic blood pressure by 0.84 mmHg (95% CI: 1.66 to 0.01) [23], a 12% reduction in the probability of high blood cholesterol [odds ratio (OR) = 0.88, 95% CI: 0.780.99] [18], a reduction in total cholesterol by 0.80 mg/dL (95% CI: 1.13 to 0.46) [24], low-density lipoprotein cholesterol (LDL-C) decreased by 4.10 mg/dL (95% CI: 5.9 to 2.23) [23], high-density lipoprotein (HDL) increased by 0.21 mg/dL (95% CI: 0.030.39) [25], and levels of C-reactive protein (CRP), an inflammatory marker decreased by 14.95% [26]

Regulatory status is subject to change