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New Poll Shows U.S. Adults Find Cigarettes Most Unsafe, Addictive Substance Southern Iowa Mental Health Center Cigarettes Are Highly Addictive What is nicotine dependence? Nicotine is the addictive ingredient in both vapes and cigarettes. When your body receives nicotine, receptors in the brain release a feel good chemical this is what makes Chemicals in Cigarettes and Tobacco: What's Burning?
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