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10.1111/j.1469-8137.2012.04111.x 101 JooJ

Irreversible heart injury is the main culprit for the poor prognosis of CVDs

Variation of Glucoraphanin metabolism in vivo and ex vivo by human gut bacteria

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin