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Functionally, these findings correlated with reduced iron availability upon dexamethasone pretreatment after 24 h of erastin treatment as assessed by flow cytometry for FerroOrange staining (Fig

[DOI] [PubMed] [Google Scholar] 166.Johnson T.E., Hermanson D., Wang L., Kassie F., Upadhyaya P., OSullivan M.G., Hecht S.S., Lu J., Xing C

In addition, the activation of SENP1-Sirt3 signaling leads to the accumulation of glutaminolytic -KG in M2 macrophages, which enhances M2 macrophage polarization through the demethylation of Jmjd3 at H3K27me3, thereby promoting tumor cell growth and survival in the TME (Fig

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