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The clinical anatomy of the phrenic ganglion

After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

175,176 This mechanism supports protective autophagy in granulosa cells and cochlear marginal cells during hypoxic stress, which is consistent with the finding that the HIF-1/Beclin1-mediated autophagy pathway confers neuroprotection under hypoxic preconditioning