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For instance, mild hypomethylation of bone-marrow MSCs amplifies their secretome and outperforms nave cells in cisplatin models, while coupling the same cells with neonatal ovarian aggregates yields an artificial ovary capable of folliculogenesis without uncontrolled proliferation

It is important to note that unlike P450, where a radical pair (both the enzyme and substrate) are caged, so the free radical (drug) is not diffusible to the medium, MPO substrates usually are not caged

Moreover, the oxidative cellular environment appears to initiate cell division in mammalian cells (Menon and Goswami, 2007

Medical and Health Science and Technology Project of Zhejiang Province (Grant No