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Lipid peroxidation products damage the majority of hepatocytes in the liver as NAFLD progresses

On the other hand, M98K OPTN overexpression in RGC-5 cells induced autophagy that led to cell death 30

Increased IL-1 levels elevate iron regulatory protein 1 and TFR1 in oligodendrocytes, while reduced iron transporter protein 1 expression leads to intracellular iron accumulation, contributing to neurodegenerative diseases (Yang J