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The genetic correlates relate primarily to variants in the genes coding for transporters controlling plasma UA, yet such presumed functional variants will also influence, through the same proteins, the transport of UA into the brain and subsequently into neurons and glia, as described below

Epigenetic age acceleration and cognitive function in African American adults in midlife: the atherosclerosis risk in communities study

Studies show it helps stop or reverse brain degeneration with Alzheimers Disease, and geriatric depression

327 Noncanonical Hippo/MST signaling via BUB3 and FOXO has also been shown to support pulmonary vascular cell growth and survival, indicating alternative regulatory mechanisms within the pathway