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Description

1,2,6,18 Patients with pernicious anemia may have hematologic findings consistent w ith normocytic anemia

Conclusion To the authors knowledge, this is the largest study to date examining patient safety and vitamin B12 deficiency

It is vital that prescribers understand the pharmacokinetics of this drug class

In this study, we screened from an in-house developed metabolites library and identified MeCbl, an endogenous coenzyme form of vitamin B12, as a potent and specific inhibitor of GSDME without any effects on GSDMD