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Earlier Inpatient Study An uncontrolled study included people admitted for alcohol or opioid withdrawal

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doi: 10.1080/13813455.2020.1797106 29 RoohiTFFaizanSParrayZABaigMMehdiSKinattingalNet al

Functionalized pyridinone- and pyridinethione-scaffolds, nicotinic-, isonicotinic-, aminobenzoic- and hydrazinobenzoic acids were prepared and examined as bioisosters, but no significant improvement of affinity was encountered by this maneuver