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Life Sci 351:122838 Hglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE (2024) A biological classification of Parkinsons disease: the SynNeurGe research diagnostic criteria

E., East, M

Conceptual schematic illustrating the attenuation of circadian rhythm amplitude and phase shifts in aging, with a particular emphasis on nocturnal melatonin decline as a central driver of sleep fragmentation, metabolic dysregulation, and reduced antioxidant capacity ( The figure highlights age-related changes in key physiological variables, including restactivity cycles, core body temperature, hormonal secretion (melatonin and cortisol), suprachiasmatic nucleus (SCN) neuronal activity, and metabolic indicators such as glucose regulation

First, profiles characterized by low or flattened salivary cortisol despite normal systemic measures motivate mechanistic investigation into peripheral hormone handling and delivery, including neutrophil-related pathways proposed in this manuscript