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The regulatory effect of GPX8 on Ca 2+ may be related to the inositol 1,4,5-triphosphate receptor (IP3R) effect, and the transmembrane domain (TMD) of GPX8 is thought to play a key role in the regulation of Ca 2+ signaling (Yoboue et al., 2017)

Long-term effects of KD The long-term safety profile of KD remains a concern due to its unconventional macronutrient distribution, characterized by high fat and low carbohydrate intake

For Cu trafficking, the negative regulatory factor of cuproptosis MTF1 is capable of binding to the metal-responsive element of ATP7B promoter, their failed interaction may contribute to the unusual Cu efflux in Wilson disease (Stalke et al., 2020)

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