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Acknowledgements This work was supported by the UKRI FLF/MRC Award MR/V026283/1 (O.U.), NIH/NIGMS R35 GM118047 (H.A.), NIH/NCI R01 CA237272 (A.M.L.), NIH/NCI R01 CA233562 (A.M.L.), a 2018 Prostate Cancer Foundation Challenge Award (A.M.L.), a Prostate Cancer Foundation Young Investigator Award (A.M.L.), and Andy North and Friends (A.M.L.)

Accordingly, we evaluated the lipid peroxidation by malonaldehyde (MDA) and also measured the antioxidant biomarker (SOD, CAT and GPx) levels in both the hippocampus and the cerebral cortex