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Targeted editing of tomato carotenoid isomerase reveals the role of 5 UTR region in gene expression regulation

Transcriptomic and unbiased metabolomic modeling in ndufs2 -/- larvae uncovered a host of dysregulated pathways and genes that may be downstream cellular effects of primary CI deficiency that significantly impact animal survival and health and thereby warrant investigation for potential therapeutic manipulation

While this mechanism explains the negative impact of ablative radiation doses on abscopal responses in a murine mammary carcinoma model (Dewan et al., 2009), the observation is not consistently held up in non-abscopal readouts of tumour immunity, suggesting that other factors may be involved in this regulation (Burnette et al., 2011