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doi: 10.1016/j.cmet.2022.08.002 89 Reina-CamposMScharpingNEGoldrathAW

Scalbert A, Johnson IT, Saltmarsh M

By inhibiting epigenetic enzymes like DNMTs, compounds such as curcumin and apigenin reduce CpG hypermethylation in the NRF2 promoter, leading to elevated NRF2 levels and offering potential therapeutic benefits for diseases associated with oxidative stress [35, 149]