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HGF/c-Met activates a diverse set of signal transducers capable of inhibiting cell death

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The study population had a mean age of 54 years and a mean BMI of 36.1 kg/m 2 and experienced a BW reduction of 12.8%, 14.7% and 3.2% with tirzepatide 10 mg, tirzepatide 15 mg and placebo, respectively, at 72 weeks 37

These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone