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The next paragraphs will discuss genetic predisposition and susceptibility as an underlying risk factor for ME/CFS - the superimposition of external stressors and exposures (59) results in a state of aberrant homeostasis, where a temporary homeostatic state of functioning occurs, but functions at a less optimum level (64)

The ligated cysteine makes an additional two hydrogen bonds to amino acid side chains, one to the Tyr10 OH atom, and one to the Tyr106 OH atom, and a further hydrogen bond to the main chain N atom of Arg16