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Peer review Peer review information Nature Communications thanks Mirjam Christ-Crain, Andreas Kronbichler and the other anonymous reviewer(s) for their contribution to the peer review of this work

Both trigger a pulse of endogenous growth hormone release, which then drives IGF-1 production downstream

A single injection of CJC-1295 with DAC can elevate IGF-1 levels for up to two weeks, a duration unmatched by any other GHRH analog studied in clinical settings