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The level of stable adducts formed by E 1 (E 2 )-2,3-Q is still lower than the level of the depurinating adducts 2-OHE 1 (E 2 )-6-N3Ade [21, 26]

doi: 10.1016/j.radonc.2018.08.016 120 RomanoFBJorgeCLerchPGDarafshehMLF

The underlying repair processes, including new blood vessel formation that studies have examined in animal models, are the plausible mechanism, though the human timeline is not precisely established