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Beyond telomerase, Epitalon has secondary effects: Melatonin restoration: Epitalon restores nocturnal melatonin secretion patterns in aged animals, improving circadian regulation Antioxidant activation: Upregulation of superoxide dismutase and catalase expression Gene regulation: The Khavinson bioregulator theory proposes direct DNA binding by short peptides, though this mechanism lacks independent structural validation Epitalon targets a single primary hallmark: telomere attrition

54,55 The impaired function of DH may lead to impaired synaptogenesis and axonal growth, manifesting as hypotonia and seizures

Incorporation of noncanonical amino acids into Rosetta and use in computational protein-peptide interface design

et al., 2021)