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It should also be noted that unlike the vitamin B-12 in foods, the purified form of B-12 found in supplements, including regular and sublingual tablets, does not require stomach acid for it to be made available for absorption

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Moreover, elevated homocysteine levels have been associated with enhanced in vivo lipid and protein oxidation in humans, as suggested by the correlation obtained between plasma homocysteine and F 2 -isoprostanes, relevant biomarkers of nonenzymatic peroxidation (Ventura et al, 2000