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Adipose tissue-derived adiponectin, 179 a type of lipokine that includes palmitoleic acid (C16:1n7), 180 contributes to interorgan communication with tissues such as the liver and muscle, with a potential role in ameliorating insulin resistance and type 2 diabetes in humans

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Dysbiosis is associated with systemic inflammation and metabolic dysfunction in diabetes, both of which can exacerbate DPN