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Previous molecular approaches 12,25 and recent multi-locus approaches 8,9 also support the polyphyletic nature of Ea

Esm1-CreERT2 -mediated loss of Itgb1 at P6 results in defective extension of tip cells in the Itgb1 i Esm1 KO mutants compaired to Itgb1 i Esm1 HET control littermates, resulting in blunt areas in the vascular plexus growing front (Supplementary Fig