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This is dependent on angiotensin II type-1 and mineralocorticoid receptors [136]

Topical diclofenac therapy for osteoarthritis: A meta-analysis of randomized controlled trials

Luciferase reporter assay A luciferase reporter plasmid, a TK-Renilla (thymidine kinase promoter-Renilla) plasmid, and other indicated plasmids were transfected into HEK293T cells using polyethylenimine