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PMID: 9005976

66 In addition, glutamine metabolism is a hot research topic

Clinically significant fluid retention could theoretically alter the volume of distribution of apixaban, though no study has quantified this effect

In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]