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The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues

[DOI] [PubMed] [Google Scholar] 7.Bewick GA, Gardiner JV, Dhillo WS, Kent AS, White NE, Webster Z, Ghatei MA, Bloom SR

(2023) 5:e00030

If adding amylin agonism to a single GLP-1 agonist (CagriSema) produces 20.4% weight loss, the theoretical potential of adding it to a triple agonist is significant