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The complication structure mirrors E11 exactly (E13.42 = polyneuropathy, E13.621 = foot ulcer, etc.)

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Among the UPR sensors accountable for the activation of ER stress pathway is protein kinase RNA-like ER kinase (PERK), where during ER stress, glucose-regulated protein 78 (GRP78) separates from PERK, thus activating PERK (Kudo et al