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Beyond its familiar role in bone and dental health, calcium is essential for muscle contraction, nerve transmission, and blood clotting

Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes

In addition, a synthetic lethal relationship exists between the oncogenic activity of IDH2 and the serine synthesis pathway in both TNBC and HER2-positive breast cancer, rendering cells with high IDH2 expression particularly sensitive to PHGDH or PSAT1 inhibition (71)