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47 Recommendation 3.1 Genetic counseling should be provided to parents with affected children and the 25% recurrence risk with regard to future pregnancies should be discussed in detail

These miRNAs and especially miR-223 which are involved in PI3K/AKT, IGF1, and MEK/ERK/NF-B signaling cascades could represent a molecular link between inflammation and cancer

AMPK is known as the master energy sensor of the cell, and its activation is generally associated with stimulating mitochondrial biogenesis and triggering autophagy, a cellular "housekeeping" process where the cell breaks down and recycles damaged organelles and misfolded proteins

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