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Thus, plasma vanin-1 concentrations in patients with CAD were found to be high and to be associated with the presence and severity of CAD

While Casp1 (which was the most highly upregulated gene when comparing mock-infected sensitized urothelia to resolved (Supplementary Table 2)) and other pyroptosis-related genes (including Aim2 , Gsdmc2 and Gsdmc3 ) were upregulated in sensitized differentiated urothelia, other pyroptosis-related genes (such as the Naips ) as well as apoptosis and necroptosis-related genes were upregulated in resolved differentiated urothelia, suggesting that resolved and sensitized cells are predisposed to different PCD mechanisms during UPEC infection