glutathione gbm6 patient derived xenograft Applications of patient-derived tumor models and tumor organoids Combined inhibition of de novo

Combined inhibition of de novo glutathione and nucleotide biosynthesis is synthetically lethal in glioblastoma ScienceDirect Catabolism of extracellular glutathione supplies cysteine to support tumours Nature CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia induced invasion, and therapeutic resistance bioRxiv Generation of orthotopic intracranial glioblastoma patient derived xenograft models: insights into extrachromosomal DNA driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic evaluation ScienceDirect

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