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Joint discomfort is not listed as a recognised adverse effect in the BNF or licensed B12 product information, and most people taking B12 experience no musculoskeletal symptoms

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According to a study published in the journal Experimental and Therapeutic Medicine , adults who were diagnosed with metabolic syndromea number of health conditions (such as high blood pressure, high blood sugar levels, high cholesterol and a large waistline) that can raise the risk of heart disease, diabetes and stroke, as defined by the National Institutes of Healthand who initially tested with higher levels of glutathione showed greater reductions in body weight and body fat percentage after following a personalized healthy eating plan for six months