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The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural

To validate NNMT as an anti-obesity drug target, we investigated the permeability, selectivity, mechanistic, and physiological properties of a series of small molecule NNMT inhibitors

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