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Taken together, these data show that NRF2 and ChaC1 negatively affect the expression of the other

ii) the DAPA group, which received daily oral gavage of DAPA (10 mg/kg/day

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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction