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Similarly, Lipid nanoparticles (LNPs) carrying indinavir (IDV) achieved higher lymph node drug levels, increased intracellular PBMC concentrations, prolonged plasma residence, restored CD4 T cells, and suppressed viral RNA in primates

There were no statistically significant differences in the parameters, neither between the experimental and control groups, nor between the initial baseline (T1) and final measurements (T4)

doi: 10.1111/imm.13462 57 KimDHLeeW-W

Additional experiments demonstrated that HO-1 induction was dependent on the TrxR redox activity since restoring intracellular levels of reduced Trx was sufficient to increase HO-1 expression when endothelial cells were cultured in Se-deficient media (less than 01 ppm Se) ( Reference Trigona, Mullarky and Cao 36 )