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Variability of gene expression identifies transcriptional regulators of early human embryonic development

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

While the diversity in 5-ALA administration methods and preparation formulations will lead to different tumor accumulation peaks of PpIX, the biodistribution of PpIX, metabolic kinetics, and intratumoral sO 2 levels before and after laser exposure are also variable due to tumor heterogeneity

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